Methyl isothiocyanate → N-methyl-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]thiourea

Reaction equation

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][N:7]=1.[CH3:14][N:15]=[C:16]=[S:17]>>[CH3:14][NH:15][C:16]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][N:7]=1)=[S:17]

Participants

Reactant 2

HCID 11167Methyl isothiocyanate

HCID 129515352-{[(3-Methoxypyridin-2-yl)methyl]sulfanyl}ethan-1-amine

Product 1

HCID 20474242N-methyl-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]thiourea

Procedure

By reaction of 2-[2-aminoethylthiomethyl]-3-methoxypyridine with methyl isothiocyanate there may be produced N-methyl-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]thiourea.

Sources & evidence

ORD record: ord-cc0b58b9b6cd404ea825c971ac592829
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04154838

Reaction notes

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