HCID 54200145, compound → HCID 54282494, compound
Reaction equation
C([S:4][CH:5]([C:16]([F:19])([F:18])[F:17])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])(=O)C>O.N>[SH:4][CH:5]([C:16]([F:19])([F:17])[F:18])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
1-(2-Acetylthio-3,3,3-trifluoropropanoyl)-L-proline (4 g.) is dissolved in a mixture of water (8 ml.) and concentrated ammonia (8 ml.) under a blanket of nitrogen. After thirty minutes at room temperature, the reaction mixture is acidified and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated to dryness in vacuo to yield 1-(2-mercapto-3,3,3-trifluoropropanoyl)-L-proline.
Workup
- waitAfter thirty minutes at room temperature
- extractionextracted with ethyl acetate
- dry with materialThe organic phase is dried over magnesium sulfate
- concentrationconcentrated to dryness in vacuo
Sources & evidence
- ORD record
- ord-eeab31b27fc7482c8aa7b27217b12c85
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04154935
Reaction notes
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