Ethanol → HCID 178512117, compound

HRID 262766Notes

Reaction equation

HRID 262766 reaction equation
I.[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8](=[NH:11])SC.[NH2:17][CH2:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.C(O)C>O>[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:4]=1[CH:5]=[N:6][NH:7][C:8]([NH:17][CH2:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)=[NH:11]

Participants

5

Reactant 3

HCID 702EthanolHCID 773174-PyridinemethanamineHCID 178504060Methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydroiodide

Product 1

HCID 178512117HCID 178512117, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 5.85 g. of methyl 3-(2,6-dichlorobenzylidene)thiocarbazimidate hydriodide and 3.24 g. of 4-(aminomethyl)pyridine in 25 ml. of absolute ethanol is heated under reflux for 24 hours and then diluted with 75 ml. of water, causing the separation of an oil. On standing, the oil crystallizes. Filtration and recrystallization from aqueous ethanol gives the desired product as colorless crystals, m.p. 159°-161° C.

Workup

  1. temperatureunder reflux for 24 hours
  2. additiondiluted with 75 ml
  3. customthe separation of an oil
  4. customthe oil crystallizes
  5. filtrationFiltration and recrystallization from aqueous ethanol

Sources & evidence

ORD record
ord-55aa7ac5eee7444ca5fc4e76b4ff03c6
Source dataset
uspto-grants-1979_05
Patent number
US04154947

Reaction notes

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