(Pyrazin-2-yl)methanamine → HCID 178506607, compound
Reaction equation
[IH:1].[C:2](=[NH:7])(SC)[NH:3][NH2:4].[NH2:8][CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1>C(O)C>[IH:1].[NH2:4][NH:3][C:2]([NH:8][CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1)=[NH:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3.66 g. of methyl thiocarbazimidate hydriodide and 3.42 g. of (aminomethyl)pyrazine [A. Hirschberg and P. Mattner, J. Med. Chem., 11, 911 (1961)] in 50 ml. of absolute ethanol is heated at reflux for 20 hours and then concentrated to dryness under reduced pressure to give the desired product as an orange solid.
Workup
- temperatureat reflux for 20 hours
- concentrationconcentrated to dryness under reduced pressure
Sources & evidence
- ORD record
- ord-e07fb3ba6e99488eb4cea33d787f021e
- Source dataset
- uspto-grants-1979_05
- Patent number
- US04154947
Reaction notes
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