2-Ethylbenzofuran → 2-Ethyl-3-(4-bromo-3-sulfamoylbenzoyl)-benzo[b]furan

HRID 263290

Reaction equation

HRID 263290 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[CH2:15]([C:17]1[O:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[CH:18]=1)[CH3:16].[Cl-].[Al+3].[Cl-].[Cl-]>CCOCC>[CH2:15]([C:17]1[O:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[C:18]=1[C:6](=[O:7])[C:5]1[CH:9]=[CH:10][C:2]([Br:1])=[C:3]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:4]=1)[CH3:16]

Participants

5

Reactant 3

HCID 765822-EthylbenzofuranHCID 6451240Aluminum(III) ChlorideHCID 213166124-Bromo-3-sulfamoylbenzoyl chloride

Product 1

HCID 213166472-Ethyl-3-(4-bromo-3-sulfamoylbenzoyl)-benzo[b]furan

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

is obtained as described in Example 1 from 10.9 g 4-bromo-3-sulfamoylbenzoyl chloride and 6 g 2-ethylbenzo[b]furan in the presence of 11.7 g aluminum chloride. Colorless crystals, m.p. 202°-206° C. (ether).

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-b8b43648ee3d490d9f43d5fdce0f7c15
Source dataset
uspto-grants-1979_05
Patent number
US04156732

Linked notes

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