Ethanol → 4-Bromo-4'-hydroxybiphenyl

HRID 26335

Reaction equation

HRID 26335 reaction equation
[OH-].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16]S(C3C=CC=CC=3)(=O)=O)=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.C(O)C>O.O1CCOCC1>[Br:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 262306[4-(4-Bromophenyl)phenyl] benzenesulfonate

Product 1

HCID 950934-Bromo-4'-hydroxybiphenyl

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

One example of a way of carrying out this Step is by a standard method using sodium hydroxide to hydrolyse commercially available 4'-bromo-4-benzene-sulphonyloxybiphenyl in a mixture of water and dioxan as solvent. The colourless crystals obtained by crystallisation of the product from ethanol have a melting point of 166° C.

Sources & evidence

ORD record
ord-1b1cf524a79c457fb18115f80b384996
Source dataset
uspto-grants-1979_04
Patent number
US04149413

Linked notes

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