Sodium Hydroxide → HCID 178526703, compound

Reaction equation

N[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[OH-:11].[Na+]>>[OH:11][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 778882-Amino-5-nitropyridine

Product 1

HCID 178526703HCID 178526703, compoundYield 60%

Conditions

Temperature: 102 °C

Procedure

A mixture containing 500 g (3.6 mol) of 2-amino-5-nitropyridine in 2000 ml of 10% sodium hydroxide was refluxed at about 102° C. for 10 hours, cooled and filtered. The filter cake was dissolved in water and neutralized with hydrochloric acid. The product was filtered and dried to give 301.7 g (60%) of product as a white powdery solid, m.p. 188°-190° C.

Workup

temperaturecooled
filtrationfiltered
dissolutionThe filter cake was dissolved in water and neutralized with hydrochloric acid
filtrationThe product was filtered
customdried

Sources & evidence

ORD record: ord-6ae7801ecbfb4c0cae743ecb62ed22a2
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04149872

Reaction notes

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