3,4-Diethoxybenzene-1-carbothioamide → 2-(3,4-Diethoxyphenyl)-4-(5-carboxy-2-pyrimidyl)thiazole
Reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([C:12](=O)[CH2:13]Br)=[N:10][CH:11]=1)=[O:5])C.[CH2:16]([O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][CH2:29][CH3:30])[C:22]([NH2:24])=[S:23])[CH3:17]>>[CH2:16]([O:18][C:19]1[CH:20]=[C:21]([C:22]2[S:23][CH:13]=[C:12]([C:9]3[N:10]=[CH:11][C:6]([C:4]([OH:3])=[O:5])=[CH:7][N:8]=3)[N:24]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH2:29][CH3:30])[CH3:17]Participants
3
Procedure
5-Ethoxycarbonyl-2-(α-bromoacetyl)pyrimidine and 3,4-diethoxythiobenzamide were subjected to the same reaction as in Example 1 and then to the same hydrolysis as in Example 147 to obtain 2-(3,4-diethoxyphenyl)-4-(5-carboxy-2-pyrimidyl)thiazole.
Workup
- customto the same hydrolysis as in Example 147
Sources & evidence
- ORD record