2-Nitrobenzoyl chloride → HCID 3352368, compound

Reaction equation

[N+](C1C=CC=C[C:5]=1[C:6](Cl)=[O:7])([O-])=O.[C:13]([NH:17][C:18](=[O:28])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N+:25]([O-])=O)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([NH:17][C:18](=[O:28])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[NH:25][C:6](=[O:7])[CH3:5])([CH3:16])([CH3:15])[CH3:14]

Participants

Reactant 2

HCID 118752-Nitrobenzoyl chloride

HCID 710774N-(tert-butyl)-2-nitrobenzamide

Product 1

HCID 3352368HCID 3352368, compound

Procedure

The method of Example 3 is repeated using 2-nitrobenzoyl chloride in the amidation step. This yields N-tert-butyl-2-nitrobenzamide (CPI1035).

Sources & evidence

ORD record: ord-d5fde2924779480fa6568049afa7831f
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05643965

Reaction notes

Loading…