4-(Dimethylamino)butyric acid hydrochloride → 4-(Dimethylamino)butanoyl chloride hydrochloride

HRID 263795

Reaction equation

HRID 263795 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:10])[CH2:4][CH2:5][CH2:6][C:7](O)=[O:8]>O=S(Cl)Cl>[ClH:1].[CH3:2][N:3]([CH3:10])[CH2:4][CH2:5][CH2:6][C:7]([Cl:1])=[O:8]

Participants

3

Reactant 1

HCID 126916404-(Dimethylamino)butyric acid hydrochloride

Product 1

HCID 190374784-(Dimethylamino)butanoyl chloride hydrochloride

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

10 g (60 mmol) of 4-dimethylaminobutyric acid hydrochloride (Janssen; Bruggen/Germany) are heated for approximately 3 h at 65° C. in 30 ml of SOCl2. SOCl2 is evaporated off and the residue is stirred to yield the title compound: TLC of a sample dissolved in methanol, Rf (U)=0.67; TLC of 4-dimethylaminobutyric acid hydrochloride, Rf (U)=0.50.

Workup

  1. customSOCl2 is evaporated off

Sources & evidence

ORD record
ord-41aced89796c40338464e2b8252692e6
Source dataset
uspto-grants-1997_07
Patent number
US05643878

Linked notes

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