Ethanolamine → 2-(Pyrimidin-2-ylamino)ethanol
Reaction equation
Cl[C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([CH2:10][NH2:11])[OH:9]>O>[N:3]1[CH:4]=[CH:5][CH:6]=[N:7][C:2]=1[NH:11][CH2:10][CH2:8][OH:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Chloropyrimidine (5 g) and ethanolamine (15 ml) were stirred for 2 hours at 140° C. After cooling, the mixture was added to water (200 ml) and continuously extracted with ethyl acetate (500 ml) for 16 hours. The organic extract was dried (MgSO4), filtered and evaporated to dryness. The title compound was obtained as a solid (m.p. 66° C.), following chromatography on silica-gel in 3% methanol in dichloromethane.
Workup
- temperatureAfter cooling
- extractioncontinuously extracted with ethyl acetate (500 ml) for 16 hours
- extractionThe organic extract
- dry with materialwas dried (MgSO4)
- filtrationfiltered
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-eec22e33ea4a4d1fbbd28342d01ac81c
- Source dataset
- uspto-grants-1997_07
- Patent number
- US05646169
Reaction notes
Loading…