Methanol → HCID 19036388, compound
Reaction equation
[CH2:1]([CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[C:8]([Cl:15])[CH:9]=[CH:10][CH:11]=2)[C:6]1=[O:16])[CH:2]=CC.C[OH:18]>ClCCl>[Cl:15][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[C:6](=[O:16])[CH:5]([CH2:1][CH:2]=[O:18])[CH2:14][CH2:13]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
7.7 g of 2-(2-buten-1-yl)-8-chloro-1-tetralone were dissolved in a mixture of 220 ml of dichloromethane and 60 ml of methanol, cooled to -75° and the double bond was ozonized in the usual manner. After flushing the reaction mixture with oxygen and argon, 4.8 ml of dimethyl sulfide were added dropwise. The mixture was left to warm slowly to room temperature and was stirred for an additional 15 hours. The crude product (10.8 g) was dissolved in about 100 ml of dichloromethane and added to a mixture of 12 ml of 10% aqueous oxalic acid, 120 g of silica gel and 300 ml of dichloromethane. The mixture was stirred at room temperature for 2 hours. 6.4 g (83%) of 8-chloro-2-(2-oxoethyl)-1-tetralone were obtained as a pale brown oil by extraction with dichloromethane.