Triethylamine → (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(4-quinolylcarbonyl)-4-piperidinamine

Participants

Reaction Steps

200 mg (0.550 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted in analogy to Example 4a with 105 mg (0.660 mmol) of quinoline-4-carboxylic acid, 168 mg (0.661 mmol) of bis(2-oxo-3-oxazolidinyl)phosphinic chloride and 169 μl (1.21 mmol) of triethylamine. The title compound ##STR85## is obtained (278 mg, 97%) as oil. TLC:methylene chloride/methanol/cone. ammonia (700:50:1) Rf =0.45, FD-MS:M+ =517, 519; IR:3395, 1755, 1620 cm-1.

Provenance & Evidence