4-Phenylcyclohexylamine → Ethyl 2,6-dimethyl-4-(4-phenylcyclohexylamino)nicotinate

Reaction equation

Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]([CH3:14])[CH:3]=1.[C:15]1([CH:21]2[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:13][C:6]1[N:5]=[C:4]([CH3:14])[CH:3]=[C:2]([NH:27][CH:24]2[CH2:23][CH2:22][CH:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:26][CH2:25]2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

Reactant 2

HCID 298974-Phenylcyclohexylamine

HCID 239536Ethyl 4-chloro-2,6-dimethylnicotinate

Product 1

HCID 19032606Ethyl 2,6-dimethyl-4-(4-phenylcyclohexylamino)nicotinate

Procedure

was prepared analogously to Example 8 using ethyl 4-chloro-2,6-dimethylnicotinate and 4-phenylcyclohexylamine. nD23 :1.5389.

Sources & evidence

ORD record: ord-3dbf6a35c51745359b624d1a6a336df2
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650417

Reaction notes

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