benzyl 4-(N,N-diethylamino)butanoate → Butyric acid, 4-(diethylamino)-
Reaction equation
[CH2:1]([N:3]([CH2:6][CH2:7][CH2:8][C:9]([O:11]CC1C=CC=CC=1)=[O:10])[CH2:4][CH3:5])[CH3:2]>[C].[Pd].C(O)C>[CH2:1]([N:3]([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH2:4][CH3:5])[CH3:2]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of benzyl 4-(N,N-diethylamino)butanoate (33.8 g), palladium-carbon (5%, 7 g) and ethanol (500 ml) was subjected to catalytic hydrogenation at room temperature and 1 atm. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 4-(N,N-diethylamino)butanoic acid (16.2 g, 75%). mp. 45°-47° C.
Workup
- customwas subjected to catalytic hydrogenation at room temperature
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-202be315fad54cc1b36e00ad8c2182b2
- Source dataset
- uspto-grants-1997_07
- Patent number
- US05650410
Reaction notes
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