Methanol → Propanoicacid, 3-phosphono-, 1-methyl ester

HRID 26656

Reaction equation

HRID 26656 reaction equation
[P:1]([CH:5]([CH3:9])[C:6]([OH:8])=[O:7])([OH:4])([OH:3])=[O:2].[CH3:10]O>>[P:1]([CH:5]([CH3:9])[C:6]([O:8][CH3:10])=[O:7])([OH:4])([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 887MethanolHCID 731872-Phosphonopropionic acid

Product 1

HCID 18623049Propanoicacid, 3-phosphono-, 1-methyl ester

Procedure

A solution of 2-phosphonopropionic acid (11.2 g., 0.073 moles) in methanol (150 ml.) is heated at reflux for eighteen hours. The methanol is removed in vacuo. Electrophoresis (0.1 N NH4HCO3, 2000 V, 20 minutes, 7.5 cm) indicates complete conversion to the desired product, methyl 2-phosphonopropionate; yield quantitative.

Workup

  1. temperatureat reflux for eighteen hours
  2. customThe methanol is removed in vacuo
  3. customElectrophoresis (0.1 N NH4HCO3, 2000 V, 20 minutes, 7.5 cm)
  4. customyield quantitative

Sources & evidence

ORD record
ord-08ed6c28926644e49ea3dd1c4b37bece
Source dataset
uspto-grants-1979_04
Patent number
US04151172

Linked notes

Loading…