Ethylene Oxide → HCID 10850080, compound

HRID 266698Notes

Reaction equation

HRID 266698 reaction equation
[CH2:1]1[O:3][CH2:2]1.[C:4]([N:8]([CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:7])[CH2:5][CH3:6]>C1(C)C=CC=CC=1.CO>[OH:3][CH2:2][CH2:1][N:18]1[CH2:17][CH2:16][CH:15]([N:8]([C:4](=[O:7])[CH2:5][CH3:6])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:20][CH2:19]1

Participants

5

Reactant 2

HCID 6354Ethylene OxideHCID 2593814-(N-Propionylaniline)piperidine

Product 1

HCID 10850080HCID 10850080, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 1140TolueneSolvent

Conditions

Temperature
15 °C

Procedure

A solution, cooled to 15° C., containing 100 mmol of ethylene oxide in toluene is added slowly to 100 mmol of 4-(N-propionylanilino)piperidine in solution in 100 ml of anhydrous methanol cooled to 15° C. After returning to room temperature and removal of the azeotrope formed by distillation, the expected product is obtained after evaporation to dryness.

Workup

  1. temperaturecooled to 15° C
  2. customAfter returning to room temperature
  3. customremoval of the azeotrope
  4. customformed by distillation

Sources & evidence

ORD record
ord-0cf41979ba5f46fc9d1a0f479f4905b6
Source dataset
uspto-grants-1997_07
Patent number
US05652246

Reaction notes

Loading…