Formaldehyde → HCID 21555828, compound

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[CH2:21]=[O:22]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[CH2:21][OH:22])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 21497380HCID 21497380, compound

Product 1

HCID 21555828HCID 21555828, compound

Procedure

In the manner given in Example 1, 5-fluoro-2-(imidazol-1-yl)benzophenone is heated in a bomb to 150° C. with 37% aqueous formaldehyde solution to give 5-fluoro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone.

Sources & evidence

ORD record: ord-8258bb448fc94cc59c59096d16feded8
Source dataset: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03941803

Reaction notes

Loading…