7-Methylbenzofuran → 7-Methyl-2-benzofurancarboxaldehyde

HRID 267651

Reaction equation

HRID 267651 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:5]=2[CH:6]=1.CC1C2[O:20]C=CC=2C=CC=1>>[CH3:11][C:10]1[C:4]2[O:3][C:2]([CH:1]=[O:20])=[CH:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 331057-Methylbenzofuran2×HCID 122548752,7-Dimethylbenzofuran

Product 1

HCID 105111537-Methyl-2-benzofurancarboxaldehyde

Procedure

i. 2.7-Dimethyl-benzofuran. 7-Methyl-benzofuran (cf. compound (2) g.) is subjected to a WILSMEYER reaction to form 7-methyl-benzofuran-2-aldehyde which is converted into 2.7-dimethyl-benzofuran by a WOLFE-KISHNER reaction by the method described in Bull, Soc. Chim. France 29, 1875 (1952). The product thus obtained has the following peaks in its MS: 146 (100%), 145 (92%) and 131 (32%).

Sources & evidence

ORD record
ord-66fef1894eb8445db95facef9b1c0b07
Source dataset
uspto-grants-1976_03
Patent number
US03943260

Linked notes

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