HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl 3-cyano-2-oxo-3-p-tolylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | p-Tolylacetonitrile | HCID 76280 | — |
| Solvent | Sodium ethoxide | HCID 2723922 | — |
| Product | Ethyl 3-cyano-2-oxo-3-p-tolylpropanoate | HCID 11481648 | — |
Reaction Steps
Following the procedures outlined in Examples 1 and 3, p-methylphenylacetonitrile and diethyl oxalate are reacted in alcoholic sodium ethoxide to obtain ethyl 3-cyano-3-(p-methylphenyl)-pyruvate, m.p. 86°-88° C. The latter is reacted with p-methylphenylacetonitrile to give 2,5-di-(p-methylphenyl)-3,4-dioxoadiponitrile, m.p. 270°-272° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03944571 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-93cc3abd2e374ecbb2212d05d7bf761a |
| Source note | uspto-grants-1976_03 |