5,6,7,8-Tetrahydro-1-naphthol → 4-(2-Methylphenyl)-1-[3-(5,6,7,8-tetrahydronaphth-1-yloxy)-prop-1-yl]-piperazine

HRID 268399

Reaction equation

HRID 268399 reaction equation
[C:1]1([O:11][CH2:12][CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3OC)[CH2:17][CH2:16]2)[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:29]1(O)C2CCCCC=2C=CC=1.ClCCCN1CCN(C2C=CC=CC=2OC)CC1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[CH3:29][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[N:18]1[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][CH2:12][O:11][C:1]2[C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[CH:4]=[CH:3][CH:2]=2)[CH2:16][CH2:17]1

Participants

5

Reactant 4

HCID 682585,6,7,8-Tetrahydro-1-naphtholHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 6226691-(3-Chloropropyl)-4-(2-methoxyphenyl)piperazineHCID 21551666HCID 21551666, compound

Product 1

HCID 215516554-(2-Methylphenyl)-1-[3-(5,6,7,8-tetrahydronaphth-1-yloxy)-prop-1-yl]-piperazine

Procedure

1-[3-(5,6,7,8-tetrahydronaphth-1-yloxy)-propyl]-4-(2-methoxyphenyl)-piperazine from 5,6,7,8-tetrahydro-1-naphthol and 1-(3-chloropropyl)-4-(2-methoxyphenyl)-piperazine; yield 48% of theory; m.p. of the dihydrochloride 202°-203°C. (decomp.).

Sources & evidence

ORD record
ord-8424f0045f994d0b8436c23596582853
Source dataset
uspto-grants-1976_03
Patent number
US03947446

Linked notes

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