Tetrafluoro-m-phenylenediamine dihydrochloride → 4-(4-Amino-2-methylphenylamino)butan-2-ol dihydrochloride
Reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][CH:13]([OH:15])[CH3:14])=[C:6]([CH3:16])[CH:5]=1)([O-])=O.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:29].Cl>[Zn].[Cl-].[NH4+].O.C(O)C>[ClH:29].[ClH:29].[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][CH2:12][CH:13]([OH:15])[CH3:14])=[C:6]([CH3:16])[CH:5]=1Participants
4
Procedure
The 4-(4-nitro-2-methylphenylamino)butan-2-ol (27) obtained above was reduced with a boiling zinc/ammonium chloride/water/ethanol mixture. The corresponding amine was isolated in dihydrochloride form.
Sources & evidence
- ORD record
- ord-4c11cee63ef64e76bcba09e523cf8b54
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07445645B2
Reaction notes
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