Ethyl isothiocyanate → N-ethyl-N'-[3-(2-pyrazinylamino)propyl]thiourea

HRID 26859

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1.[CH2:12]([N:14]=[C:15]=[S:16])[CH3:13]>>[CH2:12]([NH:14][C:15]([NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)=[S:16])[CH3:13]

Participants

Reactant 2

HCID 10966Ethyl isothiocyanate

HCID 143974072-(3-Aminopropylamino)pyrazine

Product 1

HCID 20557740N-ethyl-N'-[3-(2-pyrazinylamino)propyl]thiourea

Procedure

Reacting 2-(3-aminopropylamino)pyrazine with ethyl isothiocyanate by the procedure of Example 53 gives N-ethyl-N'-[3-(2-pyrazinylamino)propyl]thiourea.

Sources & evidence

ORD record: ord-b09de27a00cc44269ab8864c1cb5f5d1
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04151288

Linked notes

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