5-Methoxy-2-methylindole → 5-Methoxy-2-methyl-N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-indole hydrochloride

HRID 268729

Reaction equation

HRID 268729 reaction equation
[ClH:1].[N:2]1([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=O)=[CH:14][CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:21][O:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][C:27]([CH3:32])=[CH:26]2>>[ClH:1].[CH3:21][O:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[N:28]([C:16](=[O:18])[C:15]1[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][N:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]3)=[CH:20][CH:19]=1)[C:27]([CH3:32])=[CH:26]2

Participants

3

Reactant 2

HCID 706425-Methoxy-2-methylindoleHCID 689636144-(3-Piperidin-1-ylpropoxy)benzoic acid hydrochloride

Product 1

HCID 179863095-Methoxy-2-methyl-N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-indole hydrochloride

Procedure

The title compound (E7) was prepared from 4-(3-piperidin-1-ylpropoxy)benzoic acid hydrochloride (D2) and 5-methoxy-2-methyl-indole using the method described in Example 5 (E5).

Sources & evidence

ORD record
ord-3c6131b266aa4698bdfc1a0d9982a7b9
Source dataset
uspto-grants-2008_11
Patent number
US07446103B2

Linked notes

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