Ethyl isothiocyanate → N-ethyl-N'-[2-((4-methyl-5-oxazolyl)methylthio)ethyl]thiourea

HRID 26879

Reaction equation

[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11].[CH2:12]([N:14]=[C:15]=[S:16])[CH3:13]>>[CH2:12]([NH:14][C:15]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11])=[S:16])[CH3:13]

Participants

Reactant 2

HCID 10966Ethyl isothiocyanate

HCID 125438634-Methyl-5-[(2-aminoethyl)thiomethyl]oxazole

Product 1

HCID 20557694N-ethyl-N'-[2-((4-methyl-5-oxazolyl)methylthio)ethyl]thiourea

Procedure

Also, reacting 5-[(2-aminoethyl)thiomethyl]-4-methyloxazole with ethyl isothiocyanate by the procedure of Example 1 gives N-ethyl-N'-[2-((4-methyl-5-oxazolyl)methylthio)ethyl]thiourea.

Sources & evidence

ORD record: ord-770306e007944c9392a8b69a2d06d21c
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04151288

Linked notes

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