5-Bromo-2-nitroanisole → 5-bromo-7-methoxy-1H-indole

Reaction equation

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-])=O)=[C:6]([O:8][CH3:9])[CH:7]=1.Br[C:14]1C=CC(OC)=C2[C:15]=1C=CN2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[C:6]([O:8][CH3:9])[CH:7]=1)[NH:10][CH:15]=[CH:14]2

Participants

Reactant 2

HCID 117464905-Bromo-2-nitroanisole

HCID 468355404-Bromo-7-methoxy-1H-indole

Product 1

HCID 198040635-bromo-7-methoxy-1H-indole

Procedure

5-Bromo-7-methoxyindole CV was prepared from 5-bromo-2-nitroanisole using the procedure described above for preparation of 4-bromo-7-methoxyindole LII (Example 13).

Sources & evidence

ORD record: ord-9a7f32de9f69455d81880aeb51d4565e
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07446118B2

Reaction notes

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