6-Bromo-1-methyl-1H-indole → 3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

HRID 268829Notes

Reaction equation

HRID 268829 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17](C1C=CC=C2C=1C(C#N)=CN2)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17]([C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH3:11])=[CH:4][CH:3]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]

Participants

3

Reactant 2

HCID 155468546-Bromo-1-methyl-1H-indoleHCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

Product 1

HCID 673550473-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl esterYield 78%

Procedure

3-(1-Methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CXLIII (78% yield) was prepared from 6-bromo-1-methyl-1H-indole using the procedure described above for preparation of 3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Sources & evidence

ORD record
ord-3466369667924574b3d20b0e7873118d
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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