2'-Benzyloxy-biphenyl-2-boronic acid → Ethyl 4-methyl-2''-[(phenylmethyl)oxy]-1,1':2',1''-terphenyl-2-carboxylate

HRID 269579

Reaction equation

HRID 269579 reaction equation
C(NC1C=C(C(OCC)=O)C(C2[C:12]([C:17]3[CH:22]=[C:21]([C:23](F)(F)F)[CH:20]=[CH:19][C:18]=3[O:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:13]C=CC=2)=CC=1)(=O)C.C1(COC2C=CC=CC=2C2C=CC=CC=2B(O)O)C=CC=CC=1.Br[C:64]1[CH:69]=CC=C[C:65]=1[C:70]1[C:71]([C:77]([O:79][CH2:80][CH3:81])=[O:78])=[CH:72][C:73]([CH3:76])=[CH:74][CH:75]=1>>[CH3:76][C:73]1[CH:72]=[C:71]([C:77]([O:79][CH2:80][CH3:81])=[O:78])[C:70]([C:65]2[C:22]([C:17]3[CH:12]=[CH:13][CH:20]=[CH:19][C:18]=3[O:27][CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[CH:21][CH:23]=[CH:69][CH:64]=2)=[CH:75][CH:74]=1

Participants

4

Reactant 3

HCID 587309902'-Benzyloxy-biphenyl-2-boronic acidHCID 58731007Ethyl 4-(acetylamino)-2''-[(phenylmethyl)oxy]-5''-(trifluoromethyl)-1,1':2',1''-terphenyl-2-carboxylateHCID 69309503Ethyl 2'-bromo-4-methyl-2-biphenylcarboxylate

Product 1

HCID 58730980Ethyl 4-methyl-2''-[(phenylmethyl)oxy]-1,1':2',1''-terphenyl-2-carboxylate

Procedure

Prepared in a similar way to ethyl 4-(acetylamino)-2″-[(phenylmethyl)oxy]-5″-(trifluoromethyl)-1,1′:2′,1″-terphenyl-2-carboxylate but using {2′-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid instead of [2-[(phenylmethyl)oxy]-5-(trifluoromethyl)phenyl]boronic acid and ethyl 2′-bromo-4-methyl-2-biphenylcarboxylate instead of ethyl 4-(acetylamino)-2′-bromo-2-biphenylcarboxylate. LC/MS t=4.11, [MH+] 423.1

Sources & evidence

ORD record
ord-129eee260339493b8790589d99367e09
Source dataset
uspto-grants-2008_11
Patent number
US07446222B2

Linked notes

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