5-Fluoro-2-nitrotoluene → 5-Fluoro-2-nitrobenzoic acid

HRID 269724Notes

Reaction equation

HRID 269724 reaction equation
[F:1]C1C=CC([N+]([O-])=O)=C(C)C=1.F[C:13]1[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[C:15]([N+:22]([O-:24])=[O:23])[CH:14]=1>>[F:1][C:21]1[CH:13]=[CH:14][C:15]([N+:22]([O-:24])=[O:23])=[C:16]([CH:20]=1)[C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 949565-Fluoro-2-nitrotolueneHCID 27374164-Fluoro-2-nitrobenzoic acid

Product 1

HCID 27374205-Fluoro-2-nitrobenzoic acid

Procedure

The starting 5-fluoro-2-nitrobenzoic acid is prepared from 5-fluoro-2-nitrotoluene using a procedure similar to that for the preparation of 4-fluoro-2-nitrobenzoic acid which follows:

Sources & evidence

ORD record
ord-a6c90eb716d54504a4353edf341ce581
Source dataset
uspto-grants-2008_11
Patent number
US07449457B2

Reaction notes

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