HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenacyl bromide → 2-[4-(3-Chloro-4-methoxymethoxyphenyl)piperazin-1-yl]-1-phenylethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| Reactant | 1-(3-Chloro-4-methoxymethoxyphenyl)-piperazine | HCID 23111401 | — |
| Product | 2-[4-(3-Chloro-4-methoxymethoxyphenyl)piperazin-1-yl]-1-phenylethan-1-one | HCID 23111474 | 16.7% |
Reaction Steps
Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(3-chloro-4-methoxymethoxyphenyl)-piperazine (924 mg) and 2-bromoacetophenone (789 mg), respectively. Thus obtained crude product was purified on silica gel column chromatography (eluent, chloroform: acetone=20:1), to provide 2-[4-(3-chloro-4-methoxymethoxyphenyl)piperazin-1-yl]-1-phenylethan-1-one (225 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07449466B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-9285a092300e433b9772f00c2f935372 |
| Source note | uspto-grants-2008_11 |