1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 4-[4-(3-Cyclo-pentylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride

HRID 269895Notes

Reaction equation

HRID 269895 reaction equation
C(OC1C=CC(N2CCN(CCCC3CCCCC3)CC2)=CC=1[Cl:30])C1C=CC=CC=1.C([O:38][C:39]1[CH:44]=[CH:43][C:42]([N:45]2[CH2:50][CH2:49][N:48]([CH2:51][CH2:52][CH2:53][CH:54]3[CH2:58][CH2:57][CH2:56][CH2:55]3)[CH2:47][CH2:46]2)=[CH:41][C:40]=1[F:59])C1C=CC=CC=1>>[ClH:30].[CH:54]1([CH2:53][CH2:52][CH2:51][N:48]2[CH2:47][CH2:46][N:45]([C:42]3[CH:43]=[CH:44][C:39]([OH:38])=[C:40]([F:59])[CH:41]=3)[CH2:50][CH2:49]2)[CH2:58][CH2:57][CH2:56][CH2:55]1

Participants

3

Reactant 2

HCID 231114081-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 231114131-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclopentylpropyl)piperazine

Product 1

HCID 231114534-[4-(3-Cyclo-pentylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride

Procedure

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclopentylpropyl)-piperazine (494 mg), to provide 4-[4-(3-cyclo-pentylpropyl)piperazin-1-yl]-2-fluorophenol hydrochloride (398 mg).

Sources & evidence

ORD record
ord-63c34ff4ba224e64bbb6bf7a39c8b536
Source dataset
uspto-grants-2008_11
Patent number
US07449466B2

Reaction notes

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