1-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine → 4-[4-(3-Cyclopentylpropyl)piperazin-1-yl]-2,5-difluorophenol
Reaction equation
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[CH:24]1([CH2:29][CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][N:35]([C:38]3[CH:43]=[C:42]([F:44])[C:41]([O:45]C)=[CH:40][C:39]=3[F:47])[CH2:34][CH2:33]2)[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([CH2:29][CH2:30][CH2:31][N:32]2[CH2:37][CH2:36][N:35]([C:38]3[C:39]([F:47])=[CH:40][C:41]([OH:45])=[C:42]([F:44])[CH:43]=3)[CH2:34][CH2:33]2)[CH2:28][CH2:27][CH2:26][CH2:25]1Participants
3
Procedure
Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(3-cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (250 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=16:1) to provide 4-[4-(3-cyclopentylpropyl)piperazin-1-yl]-2,5-difluorophenol (83 mg).
Workup
- custom