Cyclopropylamine → HCID 28390698, compound

HRID 270065

Reaction equation

HRID 270065 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>>[CH:14]1([NH:17][C:4](=[O:6])[C:3]2[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[CH:11][C:2]=2[OH:1])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 79523Methyl 4-methoxysalicylate

Product 1

HCID 28390698HCID 28390698, compound

Procedure

A suspension of methyl 2-hydroxy-4-methoxybenzoate (5.1 g, 28.0 mmol) in cyclopropyl amine 24 mL) was stirred at room temperature for 5 days. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether) to give the subtitled compound (1.8 g).

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether)

Sources & evidence

ORD record
ord-28b3b4d48a0f4850b7c740c5ce9c9a29
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Linked notes

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