2-Amino-4-chlorophenol → 2-Acetylamino-4-chlorophenol

HRID 270071

Reaction equation

HRID 270071 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CO>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([OH:9])=[C:2]([NH:1][C:10](=[O:12])[CH3:11])[CH:7]=1

Participants

4

Reactant 2

HCID 72652-Amino-4-chlorophenolHCID 7918Acetic Anhydride

Product 1

HCID 952582-Acetylamino-4-chlorophenolYield 80.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2-amino-4-chlorophenol (1.43 g, 10.0 mmol) in methanol was added acetic anhydride (0.945 mL, 10.0 mmol) and the reaction mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo to give the subtitled compound (1.5 g).

Workup

  1. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-40c22dff81724e1d9b69e1626f222a07
Source dataset
uspto-grants-2008_11
Patent number
US07449475B2

Linked notes

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