(2-Methoxyethyl)(methyl)amine → HCID 22313912, compound

Reaction equation

[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:13]3[CH:14]=[CH:15][C:16]([C:18]#[C:19][CH2:20][CH2:21]O)=[CH:17][C:12]=3[S:11][N:10]=2)=[CH:5][CH:4]=1.[CH3:25][O:26][CH2:27][CH2:28][NH:29][CH3:30]>>[CH3:25][O:26][CH2:27][CH2:28][N:29]([CH3:30])[CH2:21][CH2:20][C:19]#[C:18][C:16]1[CH:15]=[CH:14][C:13]2[C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:24])([F:23])[F:1])=[CH:4][CH:5]=3)=[N:10][S:11][C:12]=2[CH:17]=1

Participants

Reactant 2

HCID 300977(2-Methoxyethyl)(methyl)amine

HCID 22313907HCID 22313907, compound

Product 1

HCID 22313912HCID 22313912, compound

Procedure

In analogy to example 19.1, 4-[3-(4-Trifluoromethyl-phenyl)-benzo[d]isothiazol-6-yl]-but-3-yn-1-ol and 2-Methoxyethylmethylamine were converted to yield (2-Methoxy-ethyl)-methyl-{4-[3-(4-trifluoromethyl-phenyl)-benzo[d]isothiazol-6-yl]-but-3-ynyl}-amine as light brown oil, MS: 419 (MH+).

Sources & evidence

ORD record: ord-ad49e5e31cc44ca798fd7a17f7d75bff
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07449483B2

Reaction notes

Loading…