ethyl 3-propyl-1H-pyrazole-5-carboxylate → 4-Chloro-5-Propyl-2H-pyrazole-3-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH2:12][CH3:13])[NH:8][N:7]=1)=[O:5])[CH3:2].[O-][Cl:15].[Na+]>C(O)(=O)C>[CH2:1]([O:3][C:4]([C:6]1[C:10]([Cl:15])=[C:9]([CH2:11][CH2:12][CH3:13])[NH:8][N:7]=1)=[O:5])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Following protocol K, 5-propyl-1H-pyrazole-3-carboxylic acid ethyl ester was treated with glacial acetic acid and NaOCl under similar reaction conditions, yieliding the title compound.
Sources & evidence
- ORD record
- ord-9bc47c78314f4e33828669c1e490f998
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07449576B1
Reaction notes
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