4-(2-Methoxy-5-nitrophenyl)morpholine → 4-Methoxy-3-morpholin-4-yl-phenylamine
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
4-(2-Methoxy-5-nitro-phenyl)-morpholine (w, 390 mg) was dissolved in 10 mL ethanol and reduced under 1 atm H2 using 10% Pd—C as a catalyst. After 14 hours, the catalyst was filtered off and the solvent was evaporated, affording 240 mg 4-methoxy-3-morpholin-4-yl-phenylamine (x) which was used without further purification: m/e: 208.12, MS (ES+): 209.2.
Workup
- filtrationthe catalyst was filtered off
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-8c8eee9f0a26434287d5f025231ce4ea
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07452873B2
Reaction notes
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