3-Chloro-5-(chloromethyl)pyridine hydrochloride → 4-[1-(2-Chloro-pyridin-5-ylmethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[ClH:16].Cl[C:18]1[CH:19]=[N:20][CH:21]=[C:22]([CH2:24]Cl)[CH:23]=1>>[Cl:16][C:19]1[CH:18]=[CH:23][C:22]([CH2:24][N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=3)[N:11]=[C:12]2[CH3:15])=[CH:21][N:20]=1Participants
3
Procedure
The title compound, MS: m/e=323.2 (M+H30), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 3-chloro-5-chloromethyl-pyridine hydrochloride.
Sources & evidence
- ORD record
- ord-fc53be558e9f4bf38119e09dd6a700fc
- Source dataset
- uspto-grants-2008_11