Thionyl Chloride → 6-Chloromethyl-2-methylpyridinium chloride
Reaction equation
O[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1.S(Cl)([Cl:12])=O>>[ClH:12].[Cl:12][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1Participants
3
Procedure
2-(Hydroxymethyl)-6-methylpyridine (3.7 g, 29.4 mmol) was added portion wise at 0° C. to thionylchloride (35 mL, 477 mmol). The reaction mixture was then stirred at room temperature for 18 h. Excess thionylchloride was removed under vacuum and the crude 2-chloromethyl-6-methyl-pyridine hydrochloride (5.1 g, light brown solid) was used without any further purification.
Workup
- customExcess thionylchloride was removed under vacuum
- customthe crude 2-chloromethyl-6-methyl-pyridine hydrochloride (5.1 g, light brown solid) was used without any further purification
Sources & evidence
- ORD record
- ord-e3da7e44a8a044e1952bd9eaa4e48c54
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07452909B2
Reaction notes
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