2-(4-Chlorophenoxy)acetaldehyde → 5-(5-{1-[2-(4-Chloro-phenoxy)-ethyl]-piperidin-4-yl}-2-pyridin-4-yl-furan-3-yl)-indan-1-one

HRID 271526

Reaction equation

HRID 271526 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[O:11][C:10]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[C:9]([C:18]3[CH:19]=[C:20]4[C:24](=[CH:25][CH:26]=3)[C:23](=[O:27])[CH2:22][CH2:21]4)[CH:8]=2)[CH2:3][CH2:2]1.[Cl:28][C:29]1[CH:38]=[CH:37][C:32]([O:33][CH2:34][CH:35]=O)=[CH:31][CH:30]=1>>[Cl:28][C:29]1[CH:38]=[CH:37][C:32]([O:33][CH2:34][CH2:35][N:1]2[CH2:2][CH2:3][CH:4]([C:7]3[O:11][C:10]([C:12]4[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=4)=[C:9]([C:18]4[CH:19]=[C:20]5[C:24](=[CH:25][CH:26]=4)[C:23](=[O:27])[CH2:22][CH2:21]5)[CH:8]=3)[CH2:5][CH2:6]2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 114806982-(4-Chlorophenoxy)acetaldehydeHCID 693146085-(5-Piperidin-4-yl-2-pyridin-4-yl-furan-3-yl)-indan-1-one

Product 1

HCID 693146585-(5-{1-[2-(4-Chloro-phenoxy)-ethyl]-piperidin-4-yl}-2-pyridin-4-yl-furan-3-yl)-indan-1-oneYield 65%

Procedure

The title compound (0.140 g, 65%) was prepared from the product of Example 31 Step 5 and (4-chlorophenoxy)acetaldehyde (Maguire et al, J. Chem. Soc., 1954, 3669) using the method of Example 32; MS(ES+) m/e 513 [M+H]+.

Sources & evidence

ORD record
ord-f231e5ca5bba44afaec8df3a3223fd5d
Source dataset
uspto-grants-2008_11
Patent number
US07452906B2

Linked notes

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