p-Chlorophenylboric acid → 4-(4-{4-[5-(4-Chloro-phenyl)-pyridin-2-yl]-but-3-ynyl}-benzyl)-morpholine

HRID 271641

Reaction equation

HRID 271641 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]#[C:9][CH2:10][CH2:11][C:12]2[CH:24]=[CH:23][C:15]([CH2:16][N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:14][CH:13]=2)=[N:6][CH:7]=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29](OB(O)O)=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:2]2[CH:3]=[CH:4][C:5]([C:8]#[C:9][CH2:10][CH2:11][C:12]3[CH:24]=[CH:23][C:15]([CH2:16][N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=3)=[N:6][CH:7]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 17810664p-Chlorophenylboric acidHCID 690796844-{4-[4-(5-Bromo-pyridin-2-yl)-but-3-ynyl]-benzyl}-morpholine

Product 1

HCID 103197794-(4-{4-[5-(4-Chloro-phenyl)-pyridin-2-yl]-but-3-ynyl}-benzyl)-morpholine

Procedure

Prepared analogously to Example 2.20c from 90 mg (0.23 mmol) 4-{4-[4-(5-bromo-pyridin-2-yl)-but-3-ynyl]-benzyl}-morpholine and 73 mg (0.47 mmol) 4-chlorophenylboric acid.

Sources & evidence

ORD record
ord-08e7c81fdffb47e495b2d2e60d8c67aa
Source dataset
uspto-grants-2008_11
Patent number
US07452911B2

Linked notes

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