Phosgene → 2,6-Dimethylpiperidine-1-carbonyl chloride

HRID 27205

Reaction equation

HRID 27205 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[NH:3]1.[C:9](Cl)([Cl:11])=[O:10]>C1C=CC=CC=1>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[N:3]1[C:9]([Cl:11])=[O:10]

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 68843Nanofin

Product 1

HCID 190706612,6-Dimethylpiperidine-1-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 50 g of 2,6-dimethylpiperidine in 300 ml of benzene is added 60 g of phosgene and the mixture is refluxed for 3 hours. The solid which had separated was filtered and the filtrate was concentrated and distilled under vacuum to obtain 2,6-dimethylpiperidinoyl chloride.

Workup

  1. temperaturethe mixture is refluxed for 3 hours
  2. customThe solid which had separated
  3. filtrationwas filtered
  4. concentrationthe filtrate was concentrated
  5. distillationdistilled under vacuum

Sources & evidence

ORD record
ord-d11774a1636640a29040ec7cd02bfe95
Source dataset
uspto-grants-1980_09
Patent number
US04220658

Linked notes

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