Hydrochloride methanol → Ethyl 3-{(2-aminoacetyl)amino}propionate monohydrochloride

HRID 272061Notes

Reaction equation

HRID 272061 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:11])=O)(C)(C)C.[ClH:20].CO>>[ClH:20].[NH2:8][CH2:9][C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:11]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 21893946Ethyl 3-(2-{(tert-butoxycarbonyl)amino}acetylamino)propionate

Product 1

HCID 22647362Ethyl 3-{(2-aminoacetyl)amino}propionate monohydrochloride

Procedure

2.0 Grams of ethyl 3-(2-{(tert-butoxycarbonyl)amino}-acetylamino)propionate were dissolved in 30 ml of 10% hydrochloric acid-methanol and stirred for 15 hours at room temperature. Upon distilling the reaction liquid off under reduced pressure, 1.52 g of the title compound was obtained.

Workup

  1. distillationUpon distilling
  2. customthe reaction liquid off under reduced pressure

Sources & evidence

ORD record
ord-2307c7390744429b96f5f0e1f5769833
Source dataset
uspto-grants-2008_11
Patent number
US07452908B2

Reaction notes

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