Isonicotinamidine → 4-Pyridin-4-yl-3,5,10-triaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene

HRID 272622

Reaction equation

HRID 272622 reaction equation
C([N:8]1[CH2:18][CH:17]2[CH2:19][CH:10]([C:11]3[CH:12]=[N:13][C:14]([CH3:20])=[N:15][C:16]=32)[CH2:9]1)C1C=CC=CC=1.C(N)(=N)C1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>>[N:25]1[CH:26]=[CH:27][C:20]([C:14]2[N:13]=[CH:12][C:11]3[CH:10]4[CH2:19][CH:17]([CH2:18][NH:8][CH2:9]4)[C:16]=3[N:15]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 409094IsonicotinamidineHCID 5983782510-Benzyl-4-methyl-3,5,10-triaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene

Product 1

HCID 688056714-Pyridin-4-yl-3,5,10-triaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene

Procedure

Following the method described in Example 13, 10-benzyl-4-methyl-3,5,10-triaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene and isonicotinamidine were converted to the title compound in 7.5% overall yield. APCl MS m/z 239.1 (M+H)+.

Sources & evidence

ORD record
ord-a5e25ec627e941a9871cece73bfc4a11
Source dataset
uspto-grants-2008_11
Patent number
US07456177B2

Linked notes

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