4-Bromo-2-methoxyphenol → 2-[(4-bromo-2-methoxyphenoxy)methyl]-1-methyl-1H-imidazole

HRID 272733

Reaction equation

HRID 272733 reaction equation
Cl.Cl[CH2:3][C:4]1[N:5]([CH3:9])[CH:6]=[CH:7][N:8]=1.[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=1>>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:3][C:4]2[N:5]([CH3:9])[CH:6]=[CH:7][N:8]=2)=[C:13]([O:18][CH3:19])[CH:12]=1

Participants

3

Reactant 2

HCID 2622344-Bromo-2-methoxyphenolHCID 27954062-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

Product 1

HCID 692189512-[(4-bromo-2-methoxyphenoxy)methyl]-1-methyl-1H-imidazole

Procedure

The title compound was prepared by substituting 2-chloromethyl-1-methyl-1H-imidazole hydrochloride and 4-bromo-2-methoxyphenol for Example 627A and Example 474, respectively, in Example 627B. MS (ESI) m/e 329 (M+H)+; 1H NMR (300 MHz, DMSO-d6) □ 7.17 (d, J=1.2 Hz, 1H), 7.11-7.15 (m, 2H), 7.05 (dd, J=8.5, 2.0 Hz, 1H), 6.85 (d. J=1.0 Hz, 1H), 5.09 (s, 2H), 3.77 (s, 3H), 3.67 (s, 3H).

Sources & evidence

ORD record
ord-9ffb9c2c213545ac924e3a5a0d398585
Source dataset
uspto-grants-2008_11
Patent number
US07456169B2

Linked notes

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