Diazomethane → Methyl 2-(2-bromoethyl)benzoate
Reaction equation
[Br:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[N+](=[CH2:15])=[N-]>CCOCC>[Br:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:15])=[O:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-(2-Bromoethyl)-benzoic acid (11.4 g, 50 mmol) is added to a solution of diazomethan in ether at 0° C. The reaction mixture is concentrated in vacuo, and the residue purified by chromatography to give the desired compound as a colourless oil.
Workup
- concentrationThe reaction mixture is concentrated in vacuo
- customthe residue purified by chromatography
Sources & evidence
- ORD record
- ord-da5ac1400293420aaaabc1b65bdad173
- Source dataset
- uspto-grants-1995_02
- Patent number
- US05387582
Reaction notes
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