HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Androstenediol diacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Androstenediol diacetate | HCID 102205 | — |
| Product | Androstenediol diacetate | HCID 102205 | — |
| Product | (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-7-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl diacetate | HCID 9886600 | — |
Reaction Steps
βAET was synthesized using 3β,17β- diacetoxyandrost-5-ene as a starting material. Chromic oxide oxidation of 3β,17β-diacetoxyandrost-5-ene in glacial acetic acid by the method of Butenandt (op. cit.) gave 3β,17β-diacetoxyandrost-5-en-7-one, (III), the intermediate for preparation of (I). Aluminum isopropoxide reduction of (III) in isopropanol by the method of Butenandt gave (I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05387583 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-f86041a7c9664c069aa7dd46a6156922 |
| Source note | uspto-grants-1995_02 |