HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[3-(4-Methoxyphenyl)propyl]glutaric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(4-Methoxyphenyl)butanal | HCID 10487555 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[3-(4-Methoxyphenyl)propyl]glutaric acid | HCID 20528827 | — |
Reaction Steps
4-(4-Methoxyphenyl)butyraldehyde (5.34 g) is reacted with cyanoacetic acid (5.15 g) and sodium hydroxide (2.74 g) in a mixture of glyme (50 ml) and water (60 ml). The mixture is treated with hydrochloric acid and processed as described in Example 2A to afford the title compound (2.1 g) which on crystallization from ethyl acetate-chloroform-hexane had a melting point of 71°-73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221725 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-343353e5d2dc4a2a924c7fd14af0282b |
| Source note | uspto-grants-1980_09 |