(6-Chloro-pyridin-2-yl)-ethanol → 1-(6-Chloropyridin-2-yl)ethanone
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:8]([C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([Cl:1])[N:7]=1)(=[O:10])[CH3:9]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 1-(6-chloro-2-pyridyl)ethanol (2.13 g) and manganese dioxide (8.4 g) in chloroform (21 ml) was refluxed for 8 hours. After cooling, the mixture was filtered through celite pad and the filtrate was evaporated in vacuo. The residue was purified by distillation under reduced pressure to give 2-acetyl-6-chloropyridine (1.84 g).
Workup
- temperaturewas refluxed for 8 hours
- temperatureAfter cooling
- filtrationthe mixture was filtered through celite pad
- customthe filtrate was evaporated in vacuo
- distillationThe residue was purified by distillation under reduced pressure
Sources & evidence
- ORD record
- ord-9867d502884147f79ba371f527185ab6
- Source dataset
- uspto-grants-1995_02
- Patent number
- US05387710
Reaction notes
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