3,4-Diaminopyridine → HCID 178441556, compound

Reaction equation

[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:9](O)(=O)[CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:10]([C:9]1[NH:8][C:7]2[CH:6]=[CH:5][N:4]=[CH:3][C:2]=2[N:1]=1)[CH2:11][CH2:12][CH3:13]

Participants

Reactant 2

HCID 59183,4-Diaminopyridine

HCID 7991Pentanoic Acid

Product 1

HCID 178441556HCID 178441556, compoundYield 99.6%

Conditions

Temperature: 70 °C

Procedure

A mixture of 3 g of 3,4-diamino-pyridine and 8.28 g of valeric acid was heated to 70° C. for 18 hours and the reaction medium was chromatographed on silica (eluant: ethyl acetatemethanol (8-2)) to obtain 4.8 g of the expected product which was used as is for the following step.

Workup

customthe reaction medium was chromatographed on silica (eluant: ethyl acetatemethanol (8-2))

Sources & evidence

ORD record: ord-ad0e57e92b4348ebbe384289d16ea0c2
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05389634

Reaction notes

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